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What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? | Masterjohn Q&A Files #295
What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? | Masterjohn Q&A Files #295
ratings:
Length:
7 minutes
Released:
Apr 29, 2022
Format:
Podcast episode
Description
Short answer: 25(OH)D is 1000 times weaker at activating the VDR than 1,25(OH)D, but 1000 times more abundant. This is why I advocate measuring both, and ultimately believe we need to create a calculated index of “biological vitamin D activity” from them. This is a clip from a live Q&A session open to CMJ Masterpass members. In addition to this episode, you can access five other free samples using this link: https://chrismasterjohnphd.substack.com/p/questions-on-vitamin-d-fatty-liver In that batch of free episodes you will also find the answers to these questions: • What's the difference between 25(OH)D and 1,25(OH)2D when it comes to the VDR? • Reversing Fatty Liver: How Long Does It Take? • What if my A1C says I'm diabetic but my CGM says I'm fine? • Will reishi, turmeric, or curcumin tank my testosterone? • The 3 Phases of Fasting: And How to Get Kicked Out of Each One If you want to become a Masterpass member so you can participate in the next live Q&A, or so you can have access to the complete recording and transcript of each Q&A session, you can save 10% off the subscription price for as long as you remain a member by using this link to sign up: https://chrismasterjohnphd.substack.com/qanda Learn more about the Masterpass here: https://chrismasterjohnphd.substack.com/about This snippet is from the July 13 AMA. The full recording and transcript is reserved for Masterpass members. Here is a preview of what’s included: • How do I know if my digestive enzymes are helping or hurting? • Why does high-dose glycine give me these terrible symptoms? • How to know if my magnesium is messing with my calcium? • Why do I have vitamin A symptoms when my lab tests are normal? • What is my favorite web site for finding enzymatic cofactors? • Potassium citrate vs potassium chloride • Major problems with B vitamin supplements • Is food sensitivity testing useful? • What nutrients might help with dihydropyrimidine dehydrogenase deficiency? • Does lipoic acid hurt methylation? • Sulfur SIBO that just won’t go away. • Using lactate, pyruvate, and ketone ratios to indicate the NADH/NAD+ ratio. • Helping bile flow without pharmaceuticals. • Managing pernicious anemia. • Do we really need to meet the RDA for calcium? • Could stretch marks be a sign of copper toxicity? • When iron saturation is driven by low binding capacity. • How do I know if I need methyl-free Bs? • What causes heat intolerance? Here’s a link to the full AMA: https://chrismasterjohnphd.substack.com/p/recording-and-transcript-of-the-june-de3 Access the show notes, transcript, and comments here.
Released:
Apr 29, 2022
Format:
Podcast episode
Titles in the series (100)
002: As the Cholesterol Consensus Crumbles, the Stance Against Saturated Fat Softens: Breaking News Undermines the Conventional Wisdom About Good Fats and Bad Fats by Mastering Nutrition