As US vaccine distribution expands to include younger healthier populations, questions about vaccine safety in women of childbearing age have become more urgent. University of Texas Southwestern Medical Center's Catherine Y. Spong, MD, and Emory University School of Medicine's Denise J. Jamieson, MD, MPH, both eminent obstetrician/gynecologists, join JAMA's Q&A series to discuss the safety of the Pfizer-BioNTech and Moderna vaccines in pregnant and nursing mothers, and in individuals trying to get pregnant. Recorded February 8, 2021. Related Article(s): Pregnancy, Postpartum Care, and COVID-19 Vaccination in 2021 COVID-19 Vaccination in Pregnant and Lactating Women Involving Pregnant Individuals in Clinical Research on COVID-19 Vaccines