Two recent studies find that COVID-19 vaccination during pregnancy is safe for infants and effective for children aged 1-4 years. JAMA Pediatrics Editor in Chief Dimitri Christakis, MD, and JAMA Pediatrics Associate Editor Alison Galbraith, MD, discuss clinical and policy implications with Grace Lee, MD, MPH, professor of Pediatrics at Stanford University School of Medicine, Palo Alto, California. Related Content: Newborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy Effectiveness of Monovalent mRNA Vaccines Against Omicron XBB Infection in Singaporean Children Younger Than 5 Years