26 min listen
Huda Zoghbi Part 2: Pathogenesis of MeCP2 Disorders
FromiBiology Podcast
ratings:
Length:
26 minutes
Released:
Dec 12, 2020
Format:
Podcast episode
Description
In her second lecture, Zoghbi explains how MeCP2 molecularly modulates neuronal function. Their studies uncovered a critical link between cytosine methylation, MeCP2, and the methylating enzyme Dnmt3a, in Rett Syndrome. They hypothesized that MeCP2 partially causes Rett-Syndrome symptoms by failure of reading methylated DNA marked by Dnmt3 and indeed showed that Dnmt3-dependent mCH plays a central role in Rett pathogenesis.
Released:
Dec 12, 2020
Format:
Podcast episode
Titles in the series (97)
Robert Singer Part 3: Imaging Translation and Degradation of Single mRNAs in Living Cells: In his last lecture, Singer continues the story of the life and death of RNA. His lab has developed several more fluorescence microscopy techniques that let them study, in real time, the translation and degradation of mRNA. by iBiology Podcast