34 min listen
Mohamed El-Brolosy: Transcriptional Adaptation to Mutations
FromiBiology Podcast
ratings:
Length:
23 minutes
Released:
Jan 11, 2022
Format:
Podcast episode
Description
Some people harbor deleterious mutations in disease-relevant genes, yet they are completely healthy. How are scientists trying to understand these so-called ‘genetic superheros’? In this Share Your Research talk, Dr. Mohamed El-Brolosy describes his thesis research in the model organism zebrafish. Dr. El-Brolosy found that genetic compensation to deleterious mutations relies on degradation of the mutant mRNA, which triggers upregulation of compensatory genes in a homology-dependent manner. These findings can inform strategies to better understand and treat genetic diseases, many of which have limited therapeutic options.
Released:
Jan 11, 2022
Format:
Podcast episode
Titles in the series (97)
Huda Zoghbi Part 1: Rett Syndrome: Genomes, Epigenomes and Neuropsychiatric conditions: Dr. Huda Zoghbi’s work has provided insight into Autism Spectrum Disorders (ASD) by focusing on Rett Syndrome, a postnatal progressive neurological disorder. By studying the genetics of Rett Syndrome, her group made the seminal discovery of X-linked Me... by iBiology Podcast