Nipam Patel Part 3: Homeotic (Hox) Genes and Evolution of Crustacean Body Plan

Jared Rutter Part 1: Mitochondria: The Mysterious Cellular Parasite: Mitochondria are integral to the metabolism of eukaryotic cells, yet many of their properties are not fully understood. In Part 1 of this iBioSeminar, Dr. Jared Rutter lays out the foundational knowledge of mitochondrial structure and origin, by iBiology Podcast

31 min listen

Jared Rutter Part 2: Mitochondrial Metabolism and Cell Decisions: In Part 2 of his talk, Rutter describes his group’s work to unravel the relationship between the activity of the Mitochondrial Pyruvate Carrier (MPC) and the behavior of numerous cell types, including cancer and stem cells. by iBiology Podcast

25 min listen

Nipam Patel Part 3: Homeotic (Hox) Genes and Evolution of Crustacean Body Plan: In his third talk, Patel explores the function of additional Hox genes in the development of crustacean body plans. Using CRISPR-Cas9 genome editing, his laboratory has characterized the expression and function of six of the nine Hox genes in Parhyale,... by iBiology Podcast

33 min listen

Huda Zoghbi Part 2: Pathogenesis of MeCP2 Disorders: In her second lecture, Zoghbi explains how MeCP2 molecularly modulates neuronal function. Their studies uncovered a critical link between cytosine methylation, MeCP2, and the methylating enzyme Dnmt3a, in Rett Syndrome. by iBiology Podcast

26 min listen

Huda Zoghbi Part 3: Possible Future Therapies for Rett Syndrome: In her third lecture, Zoghbi explores possible therapies for MECP2 disorders. First, using Deep Brain Stimulation (DBS), Zoghbi’s team together with collaborator Dr. Jianrong Tang were able to rescue learning and memory deficits, enhance neurogenesis, by iBiology Podcast

27 min listen

Jan-Michael Peters Part 2: How do Cohesin and CTCF Fold DNA in Mammalian Genomes?: In his second talk, Peters presents evidence that cohesin is indeed necessary for genomic DNA to fold into loops. Long range DNA interactions such as loops can be detected using a technique called Hi-C. Using Hi-C, by iBiology Podcast

36 min listen

Mana Parast Part 1: What is the Placenta?: Dr. Mana Parast provides an introduction to placental development, the organ that every mammalian embryo needs for proper growth and development. The placenta derives from trophoblasts, embryonic cells located in the outermost layer of the embryo. by iBiology Podcast

12 min listen

Nico Stuurman: Introduction to Image Acquisition for Quantitative Analysis: How do we visualize biological samples? In this talk, Dr. Nico Stuurman provides an overview of the different tools, equipment, and software available to acquire an image of a biological sample using a light microscope, by iBiology Podcast

30 min listen

Nipam Patel Part 2: The Role of Ubx in the Development of Crustacean Body Plan: In the second lecture, Patel describes the work of his lab to expand the studies of Hox gene function to other arthropods. Patel describes the development of specialized body parts in crustaceans, and describes the transition between feeding to locomo... by iBiology Podcast

34 min listen

Sven Truckenbrodt: X10 Expansion Microscopy: In the cytoplasm of cells, thousands of tightly packed molecules and structures execute the numerous processes necessary to maintain life. Although there are many ways to study cellular processes, one of the simplest ways to understand the different pa... by iBiology Podcast

35 min listen

Esteban Burchard Part 1: Racial Bias in Science and Medicine: Who’s Included?: There is ample evidence that race can be a major factor in health outcomes. But racial and ethnic minorities are underrepresented in clinical and biomedical research. In this series, Dr. Esteban Burchard talks about the consequences of this underrepres... by iBiology Podcast

5 min listen

Robert Singer Part 1: Seeing is Believing: Imaging the Expression of Genes within Single Cells: In this series of lectures, Dr. Robert Singer explains how it is possible to follow a single mRNA molecule from its birth to its death. Singer begins by explaining that cell cultures are heterogeneous and analyzing single cells provides spatial and tem... by iBiology Podcast

35 min listen

Nipam Patel Part 1: Patterning the Anterior-Posterior Axis: The Role of Homeotic (Hox) Genes: Homeotic (Hox) genes are transcription factors that dictate the development and compartmentalization (regionalization) of body parts in animals along the anterior-posterior (head to tail) axis. Using various insects and crustaceans, Dr. by iBiology Podcast

35 min listen

Mana Parast Part 2: Modeling Placental Development: In her second seminar, Parast explains the different models to study human placental development in-vitro. Scientists can derive induced pluripotent stem cells (iPSCs) from umbilical cord cells. Parast’s laboratory first differentiates the iPSCs into t... by iBiology Podcast

16 min listen

Loic Royer: Multi-Dimensional Microscopy Datasets: Storing, Processing, and Visualizing: Modern microscopy produces large multi-dimensional datasets, which creates new challenges for data storage, processing and visualization. In this talk, Dr. Loic Royer uses a developing drosophila melanogaster embryo to explain how to solve some of the ... by iBiology Podcast

20 min listen

Huda Zoghbi Part 1: Rett Syndrome: Genomes, Epigenomes and Neuropsychiatric conditions: Dr. Huda Zoghbi’s work has provided insight into Autism Spectrum Disorders (ASD) by focusing on Rett Syndrome, a postnatal progressive neurological disorder. By studying the genetics of Rett Syndrome, her group made the seminal discovery of X-linked Me... by iBiology Podcast

34 min listen

Rebecca Calisi Rodríguez: Charting an Original Path: Rebecca Calisi Rodríguez’s research on pigeons, like her life, is one of charting an original path. Her experiences as a Mexican-Italian-American woman, professor, artist and mother have provided her with fascinating and unusual perspectives to study t... by iBiology Podcast

10 min listen

Jan-Michael Peters Part 1: Cohesin: Roles Beyond Sister Chromatid Cohesion?: It has been known for many years that the protein cohesin is necessary to join sister chromatids together before they are segregated during mitosis. Electron micrographs have shown that cohesin subunits form a ring complex which is thought to encircle... by iBiology Podcast

33 min listen

Jason Swedlow: Metadata in BioImaging: Management, Organization, and Sharing BioImaging Data: In order to understand an image of a biological sample and what it represents, one needs to understand its metadata. Metadata is the information behind the image that shows the experimental procedure, image acquisition settings, by iBiology Podcast

23 min listen

Robert Singer Part 3: Imaging Translation and Degradation of Single mRNAs in Living Cells: In his last lecture, Singer continues the story of the life and death of RNA. His lab has developed several more fluorescence microscopy techniques that let them study, in real time, the translation and degradation of mRNA. by iBiology Podcast

26 min listen

Jennifer Doudna: Genome Engineering with CRISPR-Cas9: Birth of a Breakthrough Technology: Jennifer Doudna tells the story of how studying the way bacteria fight viral infection turned into a genomic engineering technology that has transformed molecular biology research. In 2013, Doudna and her colleagues developed the CRISPR-Cas9 gene expre... by iBiology Podcast

17 min listen

Robert Singer Part 2: RNA Localization: Following Single mRNAs from Birth to Death in Living Cells: To understand the relationship between RNA localization and translation, it is necessary to visualize the movement of the RNA in real time. In his second lecture, Singer explains how his lab found an ingenious way to label RNAs in live cells and follow... by iBiology Podcast

41 min listen

Conversations in Science with Dan Rather and Jennifer Doudna: The Discovery of a Gene Editing Technology: In the last few years, the term CRISPR has exploded on the global scene, and with it UC Berkeley professor Jennifer Doudna, one of the pioneers in the field, has emerged into the spotlight. From magazine covers, to news broadcasts, to social media, by iBiology Podcast

38 min listen

Esteban Burchard Part 3: Inclusion of Minorities in Science and Medicine: An Inclusive Future: There is ample evidence that race can be a major factor in health outcomes. But racial and ethnic minorities are underrepresented in clinical and biomedical research. In this series, Dr. Esteban Burchard talks about the consequences of this underrepres... by iBiology Podcast

7 min listen

Christian Tischer: Introduction to Bioimage Analysis: Microscopy is a key technology driving biological discovery. Nowadays, microscopy based scientific findings must be substantiated by quantitative image analysis. The discipline concerned with such quantification of biological microscopy images is calle... by iBiology Podcast

25 min listen

Conversations in Science with Dan Rather and Dalai Lama: Meditation and the Brain: The Dalai Lama has always had a keen interest in science. In this interview from 2008, Dan Rather and His Holiness talk science and what we can learn from the practice of meditation. This interview was filmed in 2008 for a series on the mind and the... by iBiology Podcast

5 min listen

Jared Rutter Part 3: Mitochondria: The Fuel and the Fire: In his Part 3, Rutter emphasizes the challenge of mitochondrial protein synthesis. How do the components of the electron transport chain (ETC) assemble in the right stoichiometry at the right time? Rutter introduces the LYR family of proteins, by iBiology Podcast

26 min listen

Manu Prakash: Scientific Curiosity: Finding Sublime in the Mundane: Manu Prakash always yearned to know the why and the how of things. As a boy in India, he spent endless hours playing outside with animals and making flammable artifacts in an abandoned lab in the basement of his home. by iBiology Podcast

9 min listen

Blake Simmons Part 2: Conversion of Biomass into Aviation Biofuels: In his second talk he reviews makeup of the plant cell wall and how hemicellulose, cellulose, and lignin can be broken down for use in aviation biofuel production. He describes the Joint BioEnergy Institute (JBEI) approach to maximize carbon efficiency... by iBiology Podcast

29 min listen

Jessica Polka Publishing in a Pandemic: The Preprint Revolution: As the COVID-19 pandemic escalated in the beginning of 2020, there was a need for the rapid dissemination of scientific information to understand everything from how the virus spreads, to how it affects the human body, by iBiology Podcast

8 min listen

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Nipam Patel Part 3: Homeotic (Hox) Genes and Evolution of Crustacean Body Plan

Nipam Patel Part 3: Homeotic (Hox) Genes and Evolution of Crustacean Body Plan

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