In this episode of TWiM, the hidden biochemical diversity in soil-dwelling Actinobacteria that could lead to a second Golden Era of antibiotic discovery, and structures of glideosome components reveals the mechanism of gliding in apicomplexan parasites. Become a patron of TWiM. Links for this episode: Cryptic or silent? (mBio) The Streptomyces chromosome (Ann Rev Gen) Engineering Nature’s Medicines (pdf) Apicomplexan glideosome (Comm Biol)