TWiM describes a potential connection between a bacterial protein that damages DNA, and human cancers, and how to synthesize antimicrobial natural products from reconstructed bacterial genomes of the Middle and Upper Paleolithic. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson, Petra Levin. Become a patron of TWiM. Links for this episode Colorectal cancer and E. coli (Nature) Natural products from ancient bacterial genomes (Science) Underexplored bacteria reservoirs of antimicrobial lipopeptides (Front Chem) Fries With That Mammoth Burger? (Mother Jones) 25-40 million year old spores (Science) 250 million year old bacterium from salt crystal (Nature) 1918 influenza with Jeffery Taubenberger (TWiV 966) Take the TWiM Listener survey! Send your microbiology questions and comments (email or recorded audio) to twim@microbe.tv