TRUE LYME: Understanding, Treating, and Thriving with Lyme Disease: A Comprehensive Guide
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It is reminiscent of the global pandemic of Syphilis although Bb is not transmitted sexually.
Most people are cured, once they are diagnosed and treated.
Physicians should have and maintain a high index of suspicion for the diagnosis of Lyme disease.
A few develop Long Lyme. Other causes of the exhaustion syndrome need to be excluded in these patients.
No diagnosis of dementia should be accepted until Neurological Lyme has been excluded.
Dogs bring ticks into the house.
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TRUE LYME - John Froude MD FRCP
© 2023 John Froude MD FRCP. All rights reserved.
No part of this book may be reproduced, stored in a retrieval system, or transmitted by any means without the written permission of the author.
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Certain stock imagery © Getty Images.
ISBN: 979-8-8230-8355-3 (sc)
ISBN: 979-8-8230-8357-7 (hc)
ISBN: 979-8-8230-8356-0 (e)
Library of Congress Control Number: 2023912958
Published by AuthorHouse 11/08/2023
15064.pngDedicated to Elaine Taylor and Marshall Berland.
Table of Contents
NINE TRUTHS ABOUT LYME
PROLOGUE
Part One
The Illness
1 Acute Lyme
2 How can you get Lyme disease and not know it?
3 Early Disseminated Lyme
4 More Early Disseminated Lyme
5 Late disseminated Lyme
6 Co-infections
Part Two
Lyme and the Exhaustion Syndrome
7 The Exhaustion Syndrome.
8 A History of Exhaustion
9 You haven’t got Lyme.
Actually, you do.
10 You have got Lyme
. Actually, you don’t.
11 Lyme Wars.
Part Three
12 Five Patients
Part Four
The Essentials
13 Borrelia burgdorferi is a spirochete.
14 The history of Borrelia burgdorferi (Bb)
15 Ticks
16 The Lyme Zone
17 Diagnostic Tests
18 Treatment Of Lyme Disease: Antibiotics
19 Treatment of Post Treatment Lyme Disease Syndrome (PTLDS).
20 Unproven treatments for Lyme
CONCLUSION
BIBLIOGRAPHY
REFERENCES
NINE TRUTHS ABOUT LYME
1. THE TYPICAL RASH IS NOT A BULL’S EYE
2. IT WAS FIRST DESCRIBED IN SWEDEN IN 1912, NOT LYME, CONNECTICUT IN 1975
3. THE LYME ANTIBODY TEST IS NEGATIVE FOR THE FIRST TWO TO EIGHT WEEKS AFTER INFECTION
4. NO DIAGNOSIS OF DEMENTIA IS ACCEPTABLE UNTIL LYME HAS BEEN EXCLUDED
5. AS LYME IS POTENTIALLY CURABLE IT SHOULD ALWAYS BE CONSIDERED IN THE DIFFERENTIAL DIAGNOSIS
6. EARLY DIAGNOSIS IS ESSENTIAL
7. CO-INFECTIONS MUST BE LOOKED FOR AND TREATED
8. IT HAS OCCURED IN ALL FIFTY OF THE UNITED STATES
9. IF IN DOUBT, TREAT
And as a bonus, ITS NAME IS LYME DISEASE NOT LYME’S DISEASE
It is named after a place not a person.
PROLOGUE
Ötzi the Iceman’s torso was found sticking out of a glacier high on a mountainside in the Austrian Tyrol near the Italian border. His whole body had been mummified by nature. A couple of German hikers found him in 1991. His corpse had lain there for 5,300 years since he had died in his 40s.
Fig01LymeOtzi.jpgCourtesy: Marco Samadelli/Institute for Mummy Studies/Eurac Research
Much would be learned from his body and his possessions. He had over a hundred tattoos on him, simple designs placed mostly over joints. In his stomach was food from a recent meal that included venison. He had a copper axe and a bow, a deerskin quiver containing flint pointed arrows. It was a blow to the head of unknowable cause that killed him.
His human DNA had features detectable in a group of modern-day Austrians who lived in the valley below. It also showed that he had genes for lactose intolerance and high cholesterol.
Bacterial DNA was also found in the mix. It came from the genus known as Spirochetae. It was identified as Borrelia burgdorferi the bacteria that causes a disease well recognized on the Eastern seaboard of the United States in the twenty first Century.
Ötzi was the first human known to have Lyme disease.
Part One
THE ILLNESS
Chapter One
ACUTE LYME
THE THREAT IN THE YARD
When an infected deer tick bites you it injects Borrelia burgdorferi (Bb), a bacteria, into your skin which makes its way to your bloodstream. Your immune system is triggered, and an acute inflammatory response follows to try and kick it out.
Lyme does not cause shaking chills and very high fevers. Throughout its course it is laid back, it is subacute. Other bacteria, such as Anaplasmosis, transmitted by the same tick that transmits Bb, are more aggressive.
Yet you are undoubtedly ill with weakness, malaise, poor appetite, aches and pains in your muscles and joints to go with your low-grade fever. It’s like the flu. You may take to your bed.
It’s been 3 to 30 days since the tick bit you and wherever it did you may notice a red spot, 5-20 cm in diameter. It can be anywhere on your body but areas where you might not notice a tick such as the hairline or behind your knee or in your armpit or on your back are more common. The tick would need to be attached to you for at least 24 hours before it injects Bb into you and if it were in a more obvious place such as on your forearm you might pull or rub it off.
The medical term for the big red spot is Erythema Chronicum Migrans (ECM). This unwieldy phrase is taken from the earliest description of the disease in Europe. Erythema means red. Chronicum is Latin for chronic. It fades over three weeks. Migrans might make you think it migrates about the body but it doesn’t, it spreads out from the spot where the tick bit you. Still, to call it an ECM is a useful shorthand. Very often the C is dropped, and the spot is called an EM.
In case you find the same term used to describe certain lesions of the tongue those have nothing to do with Lyme.
In popular speech it is called the bullseye
or typical bullseye rash
.
These are some examples of the typical rash of Lyme and as you can see, it is NOT a bullseye.
15020.png14984.pngFig12LymeFroude.jpgThis man was thought to
have athlete’s foot!
The presence of a flu like illness and a typical rash is diagnostic of acute Lyme disease, which is straightforward in an endemic area such as the Northeastern United States. Treatment with antibiotics should be started. Antibody tests at this time will be negative but can be tested for again at four to eight weeks. They will become positive if it is Lyme disease with or without treatment. Treatment of Acute Lyme is highly successful with over 90% cure of the acute infection with three to four weeks of doxycycline (not to be used in pregnant or lactating women). It used to be said that doxycycline should not be used in children under the age of 8 because it would damage their teeth. Although true of a similar antibiotic, tetracycline, it is not true of doxycycline. You must also warn patients that exposure to the sun while taking doxycycline can lead to severe sunburn.
An alternative is amoxicillin or cefuroxime axetil. Since the overwhelming majority are cured by this treatment most patients do not return for the blood test at four to eight weeks, even if the physician strenuously recommends it. Why go to the doctor if you feel well?
If an infected patient is not treated the acute flu like illness will resolve by