The Best Practice Is The Lowest Effective Dose Your Third Psychiatric Consultation: Diet, Exercise, and Sleep Trump Medications Medication is the Last Option Your Fourth Psychiatric Consultation
By William Yee
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The Best Practice Is The Lowest Effective Dose Your Third Psychiatric Consultation - William Yee
The Best Practice Is
The Lowest Effective Dose
Your Third Psychiatric Consultation
Copyright Applied for 11/03/2019,
All rights reserved, William R. Yee M.D., J.D.
In most cases the best practice is the lowest effective dose of medications. When higher doses are used there must be a significant and substantial justification for using more than the lowest effective dose.
Massive doses of antibiotics for rapid resolution of a fulminant (rapidly progressive) infection in an immune compromised patient is an example of a reasonable exception.
Massive doses are rarely justified because of the risks of respiratory arrest, cardiac arrest, liver failure and renal failure resulting in death. Death trumps any putative benefit of convenience or cost that massive doses of psychotropic medications might reap for the hospital, prison or nursing home.
The patient, family, medical student, law student, MBA in hospital administration and other stake holders need to know why the lowest effective dose is the best practice.
Page 1 of 66
The first principle that the stakeholders should understand is the notion of physiologic reserves.
Physiologic reserves are the excess liver capacity, the excess renal capacity, the excess buffering for exposure to acids or bases, the excess tolerance to heat or cold, the excess tolerance to carbon monoxide, the excess capacity to tolerate atropine, or QT prolonging drugs before there is permanent injury or death. Other parameters are easily found by looking at the list of side effects in the FDA Prescription Drug Labeling. This includes the prescribing information, package insert, professional labeling, direction circular and package circular.
I suggest the reader log on to the internet and find the package insert, the professional labeling, the direction circular and the package circular for any medication that they, their family and friends take.
Before the patient takes the first pill he should read and understand the package insert that is given by the pharmacy with the medication.
Page 2 of 66
My exposure to psychotropic medications began in Lafayette Clinic, in Detroit Michigan in 1972.
Lafayette Clinic was a psychiatric hospital operated by the Michigan Department of Mental Health.
At one time there were sixteen state psychiatric hospitals in Michigan.
At this time there are only three state psychiatric hospitals in Michigan:
1. Caro Center, in Caro, Michigan 2. Kalamazoo Psychiatric Center, in
Kalamazoo, Michigan and
3. Walter Reuther Psychiatric Hospital, in
Westland, Michigan
Lafayette Clinic was unique among the state operated hospitals in Michigan. It was a research hospital under the direction of Dr. Jacques Gottlieb.
All the patients admitted to Lafayette Clinic had to sign consent to be part of experimental research that could be published.
Page 3 of 66
I was told that one research project involved ten to fifteen grams of