28 min listen
S3:E3 - A chemist, a physicist and an enzyme walk into a bar...
FromPharm to Table
ratings:
Length:
35 minutes
Released:
Feb 20, 2024
Format:
Podcast episode
Description
Nadine Kuhl (process chemist) and Jacob Forstater (engineer and physicist) join the pod to share a pretty neat story that had its origins from a chemical catalog brochure advertising a new and green solvent called Cyrene. From that brochure blossomed a really amazing biocatalytic transamination to make a key chiral amine building block. In order to make this process more robust and tolerant of organic solvents, the team immobilized the transaminase enzyme and leveraged a Spinchem rotating bed reactor (we also had no idea what this was, but now we do) to make a robust process. We learned a lot on this episode, and we hope you do too!
Read the papers we discussed today:
Amination of a green solvent via immobilized biocatalysis for the synthesis of nemtabrutinib - ACS Catalysis
Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene - Green Chemistry
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
Read the papers we discussed today:
Amination of a green solvent via immobilized biocatalysis for the synthesis of nemtabrutinib - ACS Catalysis
Utilizing biocatalysis and a sulfolane-mediated reductive acetal opening to access nemtabrutinib from cyrene - Green Chemistry
Follow the Pharm to Table podcast on Twitter - @PharmtoTablePod
Visit our website at https://podcasters.spotify.com/pod/show/pharm-to-table
Released:
Feb 20, 2024
Format:
Podcast episode
Titles in the series (38)
S1.E4: Does HTE stand for Hazmat Trucking Enforcement? by Pharm to Table