Could you imagine a condition that affects virtually every organ, eludes the standard diagnostic criteria, and causes multi-system inflammation? Meet the perplexing world of mast cell activation syndrome (MCAS). MCAS is an elusive condition that affects many, yet remains largely misunderstood. MCAS is a syndrome that triggers multi-system inflammation, and due to its diverse range of symptoms, it often eludes typical diagnostic processes. It has a profound impact on both the body and mind. Mast cells are integral to our innate immune system, playing a crucial role in safeguarding us against foreign invaders, allergens, and environmental toxins. However, potential triggers of mast cell hyperactivity can range from environmental toxins to mold.   Today I’m with Dr. Bruce Hoffman and we dissect this complex condition and delve into the critical role of mast cells in our immune system. Learn how mast cells, our body's fierce protectors against toxins, might turn hyperactive due to triggers like environmental toxins, heavy metals, or mold, launching a cell danger response that could send your body into a protective shutdown. The conversation takes a deeper turn as we explore the intersection of physical and mental health. Focusing on those battling MCAS and early developmental trauma, Dr. Hoffman shares invaluable self-regulation strategies and lends insight into the significance of neurofeedback and building a window of tolerance.    Dr. Hoffman is board-certified and has a fellowship in anti-aging medicine as well as a Master’s degree in clinical nutrition. He is also a certified functional medicine practitioner. In addition to his clinical training, Dr. Hoffman has studied with many of the leading mind-body and spiritual healers of our times, including Deepak Chopra, Paul Lowe, Osho, Ramesh Balsekar, and Jon Kabat-Zinn. He has shared the stage with Dr. Deepak Chopra, Dr. John F. Demartini, and he continues to spread his inspiring vision of healing and wellness with audiences and patients around the world.   Thank you to our sponsors for making this episode possible: Mitopure: Use code NAT10 for 10% your order at https://www.timelinenutrition.com/shop/nutrition LMNT: Use Drinklmnt.com/NAT to get 8 free single serves with any order to try different flavors. Profound Health: Use code longevity15 to save 15% off your first order at https://profound-health.com/   Find more from Nathalie: YouTube: https://www.youtube.com/channel/UCmholC48MqRC50UffIZOMOQ Facebook Group: https://www.facebook.com/groups/biohackingsuperhumanperformance Instagram: https://www.instagram.com/nathalieniddam/ Website: www.NatNiddam.com Join Nat’s Membership Community: https://www.natniddam.com/bsp-community Work with Nat: Book Your 20 Minute Optimization Consult: https://calendly.com/nniddam/intro-call?month=2021-08   Find more from Dr. Bruce Hoffman: Website: https://hoffmancentre.com/   What we discuss: (0:03:00) - Understanding Mast Cell Activation Syndrome (0:15:27) - Treating Physical and Mental Health Impacts (0:23:09) - Understanding and Healing Unconscious Dynamics (0:38:05) - Treatment and Management of Histamine Intolerance (0:45:12) - Building Resilience and Shifting Healthcare Paradigms (0:57:19) - New Health Curriculum for Transformation   Key takeaways: Mast Cell Activation Syndrome (MCAS) is a condition where mast cells, a component of our immune system, become hyperactive and trigger inflammation across multiple systems in the body. This can result in a wide range of symptoms and can be difficult to diagnose. Potential triggers of this hyperactivity can include environmental toxins, mold, and certain foods. Physical and mental health are interconnected when it comes to MCAS. Individuals with this syndrome may have early developmental trauma which can exacerbate symptoms. Learning self-regulation techniques, such as neurofeedback, can be beneficial for managing stress and promoting balance in the body and mind. The treatment and management