In this installment, Contributing Editor Dr. Loretta Nastoupil has a conversation with Dr. Melody Smith. They discuss a Nature Medicine article covered by Dr. Nastoupil in her most recent Diffusion article titled, “Trust Your Gut: Changes in Intestinal Microbiome Are Associated With Outcomes Following CAR-T Therapy.” In the article, Dr. Nastoupil discusses a study that explored whether antibiotic exposure or fecal microbiome composition was associated with efficacy and toxicity following anti-CD19 chimeric antigen receptor T-cell therapy in adult patients with B-cell malignancies. You can access her Diffusion article online at https://ashpublications.org/thehematologist/article/doi/10.1182/hem.V19.4.202247/485636/Trust-Your-Gut-Changes-in-Intestinal-Microbiome.Music: “Jellyfish in Space” Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 creativecommons.org/licenses/by/3.0/