In this installment, Contributing Editor Dr. David Rees has a conversation with Drs. Naja Nyffenegger and Vania Manolova. They discuss the Blood article covered by Dr. Rees in his most recent Diffusion article titled, “Iron-restricted Erythropoiesis in Sickle Cell Disease.” In the article, Dr. Rees explored the study by Dr. Nyffenegger and colleagues, which hypothesized that iron restriction via blocking ferroportin might reduce sickle hemoglobin concentration in red blood cells, thereby decreasing hemolysis, improving blood flow, and preventing vaso-occlusive events. You can access his Diffusion article online at https://ashpublications.org/thehematologist/article/doi/10.1182/hem.V19.5.202256/486443/Iron-restricted-Erythropoiesis-in-Sickle-Cell.Music: “Jellyfish in Space” Kevin MacLeod (incompetech.com). Licensed under Creative Commons: By Attribution 3.0 creativecommons.org/licenses/by/3.0/