On this episode I breakdown nitrofurantoin pharmacology. Nitrofurantoin is an antibiotic that is used in the treatment of UTI's.



Nitrofurantoin has activity by creating reactive metabolites that can disrupt protein synthesis and ultimately kills the bacteria causing the infection.



It is important to remember with nitrofurantoin, that in the setting of systemic infection and/or kidney involvement, the drug may not be very effective.



Nitrofurantoin can potentially reduce the effectiveness of certain vaccines. Be sure to look this up prior to administration.



Nitrofurantoin can cause pulmonary symptoms as well as neuropathy. This is very important to monitor for.