JAMA Network Open Editor Frederick Rivara, MD, MPH, discusses approaches to reducing firearm violence with several JAMA Viewpoint authors: Sandro Galea, MD, DrPH (Boston University), Elinore J. Kaufman, MD, MSHP (University of Pennsylvania), and Roger A. Mitchell Jr, MD (Howard University). Topics include the state-level response to firearm-related harms, the paucity of data on firearm violence, and the pervasive health effects of firearm violence on neighborhoods and in the carceral system. Related Content: The Epidemiology of Firearm Injuries in the US: The Need for Comprehensive, Real-time, Actionable Data Violence and the Carceral State: A Public Health Continuum State Firearm Laws and Firearm-Related Mortality and Morbidity Examining the Impact of Firearm Safety Laws on Suicides Physicians and EMS Who Responded to Mass Shootings Develop Consensus Recommendations for Improving Care Approaches to Reducing Firearm Violence