This is one of our "Primer" episodes, in which Alison and Dan discuss the science of genome mining. We talk about the California Gold Rush (it's relevant! I promise!), talk about how genome sequencing has changed genome mining over the years, and we talk about a new publication out of the JGI in which Dan conducted genome mining on metagenome-derived genomes. Check out http://naturalprodcast.com for show notes with links to papers and other learning resources. Transcript at https://jgi.doe.gov/natural-prodcast-episode-10-primer-genome-mining/