The first draft of the human genome came with a price tag running into billions of dollars. In less than twenty years, the cost of whole genome sequencing had plummeted, making the thousand dollar genome a reality by 2014, and opening up a consumer market for personal genome sequencing - although as geneticist Elaine Mardis quipped, it’s a $1000 genome, and a £100,000 analysis. The price for sequencing continues to fall, and several companies are vying to be the first to break the hundred dollar barrier.But, according to George Church, professor of genetics at Harvard Medical School and one of the world’s leading authorities on genes and genomes, we’re about to see the dawn of the zero dollar genome, making personal whole genome sequencing effectively free in exchange for the data.We also chat with genomics researcher Manuel Corpas about how his experience of personal genome sequencing became very personal once he got his whole family involved, particularly when everyone started competing to see who had the 'best' genes. Genetics Unzipped is written and presented by Kat Arney, and produced by First Create the Media for the Genetics Society - one of the oldest learned societies in the world dedicated to supporting and promoting the research, teaching and application of genetics. Production by Hannah Varrall.Full show notes and links available at https://geneticsunzipped.com/blog/2019/5/9/the-zero-dollar-genome