Fexofenadine is a 2nd generation antihistamine that is primarily used for allergic rhinitis. I cover fexofenadine pharmacology on this podcast episode.



Fruit juices can actually impair the absorption of fexofenadine and increase the risk of treatment failure.



Fexofenadine is mildly anticholinergic but overall has low to no CNS penetration.



Because fexofenadine has low CNS penetration, the risk for sedation and dizziness is much lower than older antihistamines like diphenhydramine.