TWiM welcomes new host Petra Levin, and explains how a small protein helps ensure that E. coli utilizes a preferred carbon source, and a screening strategy to identify inhibitors of the type IV secretion system that is essential for virulence of a variety of bacterial pathogens. Become a patron of TWiM. Links for this episode A small protein regulates carbon utilization (PNAS) Inhibitors of type IV secretion systems (mBio) Letters read on TWiM 262 TWiM Listener survey