This audio program discusses the relationship between nearly 100 candidate genes and 12 endophenotypes for schizophrenia; the metabolic effects of switching from olanzapine, quetiapine, or risperidone to aripiprazole; the role of genetics in posttraumatic stress disorder; the relationship between depressive symptoms and inflammation in patients with coronary heart disease; a research article reporting a surprisingly high prevalence of autism spectrum disorder in a total population sample; and a clinical case conference about a suicidal man with an unexpected diagnosis of autism spectrum disorder. Articles can be viewed online at www.ajp.psychiatryonline.org.