This audio program discusses treatment of children for whom the differential diagnosis includes bipolar disorder and attention deficit hyperactivity disorder; placebo response in antidepressant trials for children; a longitudinal study comparing cortical thickness in patients with ADHD who took stimulants, patients who didn’t take stimulants, and normally developing youths; an examination of the volume and shape of the basal ganglia in ADHD conducted with large-deformation diffeomorphic metric mapping; a study of disorder-specific brain dysfunction in boys with ADHD only and boys with conduct disorder only; and a report on repeat incarcerations for prisoners with serious mental illness. Articles can be viewed online at www.ajp.psychiatryonline.org.