This audio program presents a case of delirium with manic symptoms in a patient with end-stage COPD, a clinical vignette about a chronically depressed woman in Iran, low dopamine transmission in the prefrontal cortex of people with alcoholism, a test of mindfulness training as a way to increase resilience in Marines before deployment, the influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in the offspring of Holocaust survivors, and the ties between the unexpected death of a loved one and psychiatric disorders across the life span. Articles can be viewed online at www.ajp.psychiatryonline.org.