Ebook285 pages7 hours
Chirality in Drug Research
Rating: 0 out of 5 stars
()
About this ebook
Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals.
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.
In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.
With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data.
In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions.
With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
Related to Chirality in Drug Research
Titles in the series (20)
BioNMR in Drug Research Rating: 0 out of 5 stars0 ratingsMolecular Biology in Medicinal Chemistry Rating: 0 out of 5 stars0 ratingsChemoinformatics in Drug Discovery Rating: 0 out of 5 stars0 ratingsChemogenomics in Drug Discovery: A Medicinal Chemistry Perspective Rating: 0 out of 5 stars0 ratingsProtein-Ligand Interactions: From Molecular Recognition to Drug Design Rating: 0 out of 5 stars0 ratingsHandbook of Molecular Descriptors Rating: 0 out of 5 stars0 ratingsCombinatorial Chemistry: From Theory to Application Rating: 0 out of 5 stars0 ratingsG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity Rating: 0 out of 5 stars0 ratingsProteomics in Drug Research Rating: 4 out of 5 stars4/5Ligand Design for G Protein-coupled Receptors Rating: 0 out of 5 stars0 ratingsVoltage-Gated Ion Channels as Drug Targets Rating: 0 out of 5 stars0 ratingsMass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery Rating: 0 out of 5 stars0 ratingsChirality in Drug Research Rating: 0 out of 5 stars0 ratingsFragment-based Approaches in Drug Discovery Rating: 0 out of 5 stars0 ratingsHigh-Throughput Screening in Drug Discovery Rating: 0 out of 5 stars0 ratingsMolecular Drug Properties: Measurement and Prediction Rating: 0 out of 5 stars0 ratingsDrug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability Rating: 5 out of 5 stars5/5Protein Therapeutics Rating: 0 out of 5 stars0 ratingsEarly Drug Development: Bringing a Preclinical Candidate to the Clinic Rating: 0 out of 5 stars0 ratingsNuclear Receptors as Drug Targets Rating: 0 out of 5 stars0 ratings
Related ebooks
Proteomics in Drug Research Rating: 4 out of 5 stars4/5Combinatorial Chemistry: From Theory to Application Rating: 0 out of 5 stars0 ratingsHigh-Throughput Screening in Drug Discovery Rating: 0 out of 5 stars0 ratingsFragment-based Approaches in Drug Discovery Rating: 0 out of 5 stars0 ratingsNuclear Receptors as Drug Targets Rating: 0 out of 5 stars0 ratingsChemoinformatics in Drug Discovery Rating: 0 out of 5 stars0 ratingsVoltage-Gated Ion Channels as Drug Targets Rating: 0 out of 5 stars0 ratingsChemogenomics in Drug Discovery: A Medicinal Chemistry Perspective Rating: 0 out of 5 stars0 ratingsMolecular Drug Properties: Measurement and Prediction Rating: 0 out of 5 stars0 ratingsMolecular Biology in Medicinal Chemistry Rating: 0 out of 5 stars0 ratingsLigand Design for G Protein-coupled Receptors Rating: 0 out of 5 stars0 ratingsG Protein-Coupled Receptors as Drug Targets: Analysis of Activation and Constitutive Activity Rating: 0 out of 5 stars0 ratingsDrug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability Rating: 5 out of 5 stars5/5Bioorganometallics: Biomolecules, Labeling, Medicine Rating: 0 out of 5 stars0 ratingsProtein-Ligand Interactions: From Molecular Recognition to Drug Design Rating: 0 out of 5 stars0 ratingsBiosimulation in Drug Development Rating: 0 out of 5 stars0 ratingsPhotoproteins in Bioanalysis Rating: 0 out of 5 stars0 ratingsBiomedical Applications of Proteomics Rating: 0 out of 5 stars0 ratingsModern Alkaloids: Structure, Isolation, Synthesis, and Biology Rating: 0 out of 5 stars0 ratingsMass Spectrometry in Medicinal Chemistry: Applications in Drug Discovery Rating: 0 out of 5 stars0 ratingsBioNMR in Drug Research Rating: 0 out of 5 stars0 ratingsProduction of Recombinant Proteins: Novel Microbial and Eukaryotic Expression Systems Rating: 0 out of 5 stars0 ratingsNitric Oxide Donors: For Pharmaceutical and Biological Applications Rating: 0 out of 5 stars0 ratingsModern Phytomedicine: Turning Medicinal Plants into Drugs Rating: 0 out of 5 stars0 ratingsPharmacokinetics and Pharmacodynamics of Biotech Drugs: Principles and Case Studies in Drug Development Rating: 0 out of 5 stars0 ratingsNanobiotechnology: Concepts, Applications and Perspectives Rating: 0 out of 5 stars0 ratingsMolecular Farming: Plant-made Pharmaceuticals and Technical Proteins Rating: 0 out of 5 stars0 ratingsDiscovery of Novel Natural Products with Therapeutic Potential Rating: 0 out of 5 stars0 ratingsHandbook of Meningococcal Disease: Infection Biology, Vaccination, Clinical Management Rating: 0 out of 5 stars0 ratingsAdvances in Drug Research Rating: 0 out of 5 stars0 ratings
Chemistry For You
The Secrets of Alchemy Rating: 4 out of 5 stars4/5General Chemistry Rating: 4 out of 5 stars4/5The Chemistry Book: From Gunpowder to Graphene, 250 Milestones in the History of Chemistry Rating: 5 out of 5 stars5/5Biochemistry For Dummies Rating: 5 out of 5 stars5/5Chemistry Workbook For Dummies with Online Practice Rating: 0 out of 5 stars0 ratingsThe Nature of Drugs Vol. 1: History, Pharmacology, and Social Impact Rating: 5 out of 5 stars5/5Dr. Joe & What You Didn't Know: 177 Fascinating Questions & Answers about the Chemistry of Everyday Life Rating: 0 out of 5 stars0 ratingsChemistry For Dummies Rating: 4 out of 5 stars4/5Mendeleyev's Dream Rating: 4 out of 5 stars4/5Stuff Matters: Exploring the Marvelous Materials That Shape Our Man-Made World Rating: 4 out of 5 stars4/5Organic Chemistry I For Dummies Rating: 5 out of 5 stars5/5MCAT Test Prep Inorganic Chemistry Review--Exambusters Flash Cards--Workbook 2 of 3: MCAT Exam Study Guide Rating: 0 out of 5 stars0 ratingsPainless Chemistry Rating: 0 out of 5 stars0 ratingsPIHKAL: A Chemical Love Story Rating: 4 out of 5 stars4/5Chemistry: a QuickStudy Laminated Reference Guide Rating: 5 out of 5 stars5/5Catch Up Chemistry, second edition: For the Life and Medical Sciences Rating: 5 out of 5 stars5/5Half Lives: The Unlikely History of Radium Rating: 4 out of 5 stars4/5College Chemistry Rating: 4 out of 5 stars4/5Elementary: The Periodic Table Explained Rating: 0 out of 5 stars0 ratingsToxic Legacy: How the Weedkiller Glyphosate Is Destroying Our Health and the Environment Rating: 5 out of 5 stars5/5A to Z Magic Mushrooms Making Your Own for Total Beginners Rating: 0 out of 5 stars0 ratingsOrganic Chemistry for Schools: Advanced Level and Senior High School Rating: 0 out of 5 stars0 ratingsOil: A Beginner's Guide Rating: 4 out of 5 stars4/5MCAT Organic Chemistry Review 2024-2025: Online + Book Rating: 0 out of 5 stars0 ratingsAP Chemistry Test Prep Review--Exambusters Flash Cards: AP Exam Study Guide Rating: 0 out of 5 stars0 ratingsChemistry Rating: 5 out of 5 stars5/5MCAT General Chemistry Review 2024-2025: Online + Book Rating: 0 out of 5 stars0 ratingsMonkeys, Myths, and Molecules: Separating Fact from Fiction in the Science of Everyday Life Rating: 4 out of 5 stars4/5
Reviews for Chirality in Drug Research
Rating: 0 out of 5 stars
0 ratings
0 ratings0 reviews
Book preview
Chirality in Drug Research - Eric Francotte
1Hd book_preview_excerpt.html
Enjoying the preview?
Page 1 of 1