Want to look cool like a toxicology consultant, sipping coffee on rounds? Ever check a patient for armpit sweat? Learn the secrets of tox from the titans of toxicology podcasting, The Dantastic Mr. Tox & Howard (AKA Dr. Dan Rusyniak and Dr. Howard Greller), as they loquaciously dish on all things tox. Topics include: how to approach the patient with an unknown overdose, are toxidromes clinically useful, clues on physical exam, is GI decontamination still recommended, and why they hate bupropion and tramadol. We recommend cautious ingestion of fluids while listening because this was a seriously funny episode. Try our Self Assessment Questions Toxicology 101 Quiz. Written and produced by: Christopher Chiu, MD; Graphics by: Beth Garbitelli; Edited by: Matthew Watto, MD Full show notes available at http://thecurbsiders.com/podcast Join our mailing list and receive a PDF copy of our show notes every Monday. Rate us on iTunes, recommend a guest or topic and give feedback at thecurbsiders@gmail.com.  Time Stamps 00:00 Disclosures 00:35 Intro 01:19 Guest bios both real and sarcastic 04:38 Getting to know our guests 06:33 Multiple choice toxicology 09:13 Book recommendations 11:30 Advice for learners and teachers 15:48 Clinical case from Kashlak Memorial Hospital 16:27 Initial approach and some thoughts on toxidromes 21:59 Physical exam, a toxicologist’s approach 27:09 Review of physiology: anticholinergic, cholinergic, sympathomimetic and how to recognize these findings on exam 34:18 Different speech patterns seen in toxicology 35:30 History taking and how much detective work is truly necessary 40:05 The approach to overdose on multiple substances or in setting of polypharmacy 45:52 Seinfeld, ipecac, and the controversy about gastrointestinal decontamination 63:10 Antidotes and when to give them 67:15 EKGs and overdose. Antidote for long QTc versus wide QRS 71:25 Tramadol and Egypt 73:45 Bupropion and bath salts 78:00 Outro Tags: antimuscarinic, anticholinergic, cholinergic, sympathomimetic, overdose, tramadol, bupropion, quetiapine, wellbutrin, seroquel, pupil, overdose, naloxone, narcar, toxicology, tox, toxidrome, poisoning, gi, decontamination, charcoal, ipecac, antidote, dantastic, howard, ekg, qrs, qtc, bicarbonate, assistant, care, doctor, education, family, foam, foamed, health, hospitalist, hospital, internal, internist, meded, medical, medicine, nurse, practitioner, professional, primary, physician, resident, student