With Brenda Moura, Military Hospital, Porto, and Faculty of Medicine of University of Porto - Portugal & Francesca Musella, Santa Maria della Grazie Hospital, Naples, Italy, Karolinska Institutet - Sweden In December´s HFA Cardio Talk, Dr. Francesca Musella interviews Dr. Brenda Moura on the emerging role of Patients´profiling in Heart Failure. The podcast starts with an overview of this emerging concept introduced by current HF guidelines, and then addresses the main benefits and practical repercussions of following this approach in clinical practice. In conclusion, the podcast underlies how tailoring HF medications prescription to each patient specific profile and personal tolerability may guide physicians to both HF medications prescription and up-tritation in real world scenarios.