Are GU Cast overly interested in PSMA imaging and theranostics??! Yep, afraid so! So no surprise that we're featuring this very interesting prospective trial published in European Urology this week. The objective is to evaluate the role of PSMA PET/CT prior to prostate biopsy ie in the early detection space. Can this augment mpMRI? Or replace it? Or is it all just madness due to profligate access to PSMA in Australia??!We are joined by PI Professor Louise Emmett, Nuclear Medicine Physician at St Vincent's in Sydney, to chat about the PRIMARY trial, and co-author Associate Professor Daniel Moon, Urologist at Peter MacCallum Cancer Centre who recruited close to 100 men into the trial (well done Dan!). And for a reality check to curb our enthusiasm, we are delighted to welcome back friend of the podcast, Professor Anwar Padhani, Oncologic Radiologist and MRI guru from Mt Vernon Cancer Centre and the Institute for Cancer Research in London. Co-hosts as ever, Professor Declan Murphy (also a co-author) and Dr Renu Eapen And yes we are cross-posting on YouTube so you can see how it all unfolds! Links:GU Cast on YouTube PRIMARY study in European Urology (paywall)Professor Emmet TwitterProfessor Padhani TwitterProfessor Padhani YoutubeAssociate Professor Moon Twitter