What if a diagnosis deemed to be a death sentence was not? That's precisely what Darren from the University of Pittsburgh Mental Center is here to discuss with us. He shares his fascinating research, redefining the narrative around nec totalis - a condition widely believed to be incompatible with life. Darren's data, spanning from 2010 to 2022, illustrates a different reality. Among 494 diagnosed cases, there were survivors, challenging the gloom-and-doom prognosis often associated with this diagnosis. The conversation takes a deeper turn as we explore the ethical implications of providing life-sustaining therapy for necrotizing enterocolitis totalis. Darren emphasizes the need for center-specific treatment plans and open dialogue with families about potential therapeutic options, despite the survival rate being low. We also delve into the improvements in nec totalis care and discuss the significance of intestinal transplants. Don't miss this enlightening discussion where we redefine the boundaries of what was once thought impossible. Darren's insights will surely make you question conventional medical wisdom and show you the true power of relentless research and innovation. As always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below. Enjoy!