33 min listen
Spilling the CAR-T on Cardiac Fibrosis
ratings:
Length:
21 minutes
Released:
May 11, 2021
Format:
Podcast episode
Description
Chimeric antigen receptor (CAR) T cell therapy has revolutionized cancer treatment by engineering our own immune cells to recognize and fight cancers that are resistant to treatments like radiation and chemotherapy. But can we use CAR T cells to treat other diseases too, like cardiac fibrosis? Cardiac fibrosis, or scarring of the heart, is common following heart attacks or prolonged hypertension. At some point, many patients require heart transplants. In this episode of Beyond the Abstract, Dan and Derek discuss how scientists at the University of Pennsylvania have created a new, cell-based therapy to fight against this scarring in the heart by taking a few tricks from the fields of cancer biology and immunology.Aghajanian et al. Targeting cardiac fibrosis with engineered T cells. Nature, September 2019. DOI: 10.1038/s41586-019-1546-z. PMID: 31511695.The information presented here is not medical advice. Please follow all guidelines from the CDC in regards to social distancing. Consult your physician on any questions regarding your personal health.
Released:
May 11, 2021
Format:
Podcast episode
Titles in the series (38)
An Astrocyte is Born by Beyond the Abstract