Post-acute sequelae of COVID-19 (PASC), also referred to as long-Covid, has been the subject of increasing amounts of research. PASC describes the ongoing, relapsing, or new symptoms or conditions present 30 or more days after infection, and it has become a major clinical and public health concern. This roundtable discussion focuses on cognitive, cardiovascular, and autoimmune effects of long-Covid. Roundtable experts include naturopathic oncologist and Editor-in-Chief of the Natural Medicine Journal, Tina Kaczor, ND, FABNO, cardiovascular expert and clinician, Daniel Chong, ND, and immunologist and professor Heather Zwickey, PhD.