DrBeen#48 Alzheimer's, Sleep Disturbance, and Brain Health


Studies present an association between APOE4 and sleep disturbance. Additionally APOE4 is linked to sleep disturbance before the onset of Alzheimer's symptoms. In ‘The Sleeping Brain’ article (see below) the authors suggest that sleep disturbance causes reduced removal of the waste products from the brain, leading to the accumulation of beta amyloids - which in turn is observed in Alzheimer's disease. Additionally, it is thought that APOE directly leads to beta amyloid metabolism disturbance. And, finally, it is thought that stress-related proteolytic cleavage of APOE4 leads to accumulation of tau proteins. Let's review the evidence.
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URL list from Monday, Feb. 20 2023
The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/
Sleep well — and reduce your risk of dementia and death - Harvard Healthhttps://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508
APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Texthttps://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y
N3 Phase of Sleep.https://chat.openai.com/chat
Understanding Delta Brain Waves And Sleephttps://www.sixstepstosleep.com/understanding-delta-brain-waves/
N3: Slow Wave Sleep | Sleepopolishttps://sleepopolis.com/education/n3-slow-wave-sleep/
Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagramhttps://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638
A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagramhttps://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972
Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagramhttps://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861
Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full
Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7
Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full
Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html
Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107
Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4
Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte
Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.

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