DrBeen#49 Norepinephrine, Glymphatic System, and Brain Health

During the wakeful hours, the production of norepinephrine increases. This increase helps with alertness, but also causes vasoconstriction. The outcome is a reduction in the interstitial fluid levels and reduction in the clearance of waste products. During sleep, NE levels reduce, reversing the above mentioned mechanisms, leading to more interstitial fluid movement and more glymphatic clearance of the waste products and better brain health.
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URL list from Monday, Feb. 20 2023
The Sleeping Brain: Harnessing the Power of the Glymphatic System through Lifestyle Choices - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7698404/
Norepinephrine: What It Is, Function, Deficiency & Side Effectshttps://my.clevelandclinic.org/health/articles/22610-norepinephrine-noradrenaline#:~:text=What%20does%20norepinephrine%20do%20in,pressure%20in%20times%20of%20stress.
Frontiers | Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targetshttps://www.frontiersin.org/articles/10.3389/fncir.2021.638007/full#:~:text=The%20locus%20coeruleus%20(LC)%2C,%2C%20cerebellum%2C%20and%20spinal%20cord.
fncir-15-638007-g001.jpg (1700×984)https://www.frontiersin.org/files/Articles/638007/fncir-15-638007-HTML/image_m/fncir-15-638007-g001.jpg
Sleep well — and reduce your risk of dementia and death - Harvard Healthhttps://www.health.harvard.edu/blog/sleep-well-and-reduce-your-risk-of-dementia-and-death-2021050322508
APOE ε4, Alzheimer’s disease neuropathology and sleep disturbance, in individuals with and without dementia | Alzheimer's Research & Therapy | Full Texthttps://alzres.biomedcentral.com/articles/10.1186/s13195-022-00992-y
N3 Phase of Sleep.https://chat.openai.com/chat
Understanding Delta Brain Waves And Sleephttps://www.sixstepstosleep.com/understanding-delta-brain-waves/
N3: Slow Wave Sleep | Sleepopolishttps://sleepopolis.com/education/n3-slow-wave-sleep/
Stage N3 of sleep. Delta waves on EEG recordings are observed.  | Download Scientific Diagramhttps://www.researchgate.net/figure/Stage-N3-of-sleep-Delta-waves-on-EEG-recordings-are-observed_fig4_280558638
A 30-second Epoch consisting of the parameters of staging sleep... | Download Scientific Diagramhttps://www.researchgate.net/figure/4-A-30-second-Epoch-consisting-of-the-parameters-of-staging-sleep-electroencephalogram_fig4_282014972
Hallmark of Stage N3 (slow-wave sleep or Stages 3 and 4 sleep: delta... | Download Scientific Diagramhttps://www.researchgate.net/figure/Hallmark-of-Stage-N3-slow-wave-sleep-or-Stages-3-and-4-sleep-delta-waves_fig1_5812861
Frontiers | Perivascular Spaces, Glymphatic System and MRhttps://www.frontiersin.org/articles/10.3389/fneur.2022.844938/full
Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology | SpringerLinkhttps://link.springer.com/article/10.1007/s00234-021-02718-7
Frontiers | Perivascular Unit: This Must Be the Place. The Anatomical Crossroad Between the Immune, Vascular and Nervous Systemhttps://www.frontiersin.org/articles/10.3389/fnana.2020.00017/full
Neuroglia Lab : Glymphatics and virchow-robin spacehttp://visnu528.blogspot.com/2014/09/glymphatics-and-virchow-robin-space.html
Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain | Neurologyhttps://n.neurology.org/content/98/3/107
Aquaporin-4 - Wikipediahttps://en.wikipedia.org/wiki/Aquaporin-4
Astrocyte - Wikipediahttps://en.wikipedia.org/wiki/Astrocyte
Neurocytology-Astrocyteshttps://neuropathology-web.org/chapter1/chapter1bAstrocytes.html#:~:text=Astrocytic%20foot%20processes%20surround%20brain,maintains%20homeostasis%20in%20the%20CNS.
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