In this review of research, we find that SARS-COV-2 (possibly directly) and COVID-19 vaccines (possibly indirectly, via anti-idiotype antibodies) can change the neuron gene expressions in the sensory ganglions. Additionally, there is a possibility of ganglion pathology due to peripheral nerve injury and systemic inflammatory molecules in the circulation. Satellite glial cells, macrophages, and other immune cells could become activated in the ganglions resulting in neuronal hyperexcitability and hyperesthesia and allodynia. Let's review.
URL list from Thursday, Nov. 30, 2023
Neuropathic Pain Associated with COVID-19: a Systematic Review of Case Reports | Current Pain and Headache Reportshttps://link.springer.com/article/10.1007/s11916-022-01065-3
Functional Anatomy of the Sensory Nervous System: Updates From the Neuroscience Bench - LaTasha K. Crawford, Michael J. Caterina, 2020https://journals.sagepub.com/doi/10.1177/0192623319869011
Tissue-resident M2 macrophages directly contact primary sensory neurons in the sensory ganglia after nerve injury - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513227/
SARS-CoV-2 airway infection results in the development of somatosensory abnormalities in a hamster model | Science Signalinghttps://www.science.org/doi/10.1126/scisignal.ade4984
Neuropathic symptoms with SARS-CoV-2 vaccination - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128783/
How Is Peripheral Injury Signaled to Satellite Glial Cells in Sensory Ganglia? - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8833977/
Neuron-associated macrophage proliferation in the sensory ganglia is associated with peripheral nerve injury-induced neuropathic pain involving CX3CR1 signaling | eLifehttps://elifesciences.org/articles/78515
Neuropathic Pain: From Mechanisms to Treatment | Physiological Reviewshttps://journals.physiology.org/doi/full/10.1152/physrev.00045.2019
ILF3 - Wikipediahttps://en.wikipedia.org/wiki/ILF3
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