Ep 28: Spike Proteins Disrupt Nitric Oxide
Let's review how the spike protein alone can cause dysregulation of the ACE2 bearning cells. One important mechanism is the reduction in the expression of the endothelial nitric oxide synthase (eNOS) enzyme. Let's review.
DrBeen: Medical Education Onlinehttps://www.drbeen.com/
FLCCC | Front Line COVID-19 Critical Care Alliancehttps://covid19criticalcare.com/
URL list from Sunday, Oct. 9 2022
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2 | Circulation Researchhttps://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902
Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8487226/
Endothelial NOS - Wikipediahttps://en.wikipedia.org/wiki/Endothelial_NOS
The novel coronavirus’ spike protein plays additional key role in illness - Salk Institute for Biological Studieshttps://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/
ACE/ACE2 balance might be instrumental to explain the certain comorbidities leading to severe COVID-19 cases - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7856554/
The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820157/
Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients - eBioMedicinehttps://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00077-9/fulltext
l-Arginine and COVID-19: An Update - PMChttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619186/
l-Arginine supplementation enhances eNOS expression in experimental model of hypercholesterolemic rabbits aorta - PubMedhttps://pubmed.ncbi.nlm.nih.gov/19168337/
Implications of SARS-Cov-2 infection on eNOS and iNOS activity: Consequences for the respiratory and vascular systems - ScienceDirecthttps://www.sciencedirect.com/science/article/pii/S1089860321000380
Induction of citrulline-nitric oxide (NO) cycle enzymes and NO production in immunostimulated rat RPE-J cells - PubMedhttps://pubmed.ncbi.nlm.nih.gov/12589771/
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