Modern neuroscience tells us how we store and process information depends upon our emotional state, which easily triggers the "fight or flight" response. Technologies that are designed to empower our understanding of events at hand, as well as to respond quickly, ultimately depend upon our personal fortitude. Large Language Model (LLM) AI has brought brand new hopes, and fears, for how we might transform the next wave of technology products and services. In this SXSW Session, John Maeda, Vice President of Design and Artificial Intelligence at Microsoft, walks us through his Design in Tech Report, focusing on exciting new developments in the fields of AI and Design.