More than 2 million individuals in the US are chronically infected with hepatitis C, and nearly 15 000 die every year. Antivirals are available but are not reaching the majority of infected individuals. In this Q&A, JAMA Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, and Francis S. Collins, MD, PhD, discuss a plan to eliminate hepatitis C included in the Biden-Harris 2024 budget proposal. Related Content: A National Hepatitis C Elimination Program in the United States Eliminating Hepatitis C in the United States Former NIH Director Francis S. Collins on the New White House Plan to Eliminate Hepatitis C Association of Direct-Acting Antiviral Therapy With Liver and Nonliver Complications and Long-term Mortality in Patients With Chronic Hepatitis C After 12 Years, NIH Director Francis S. Collins, MD, PhD, Seeks His Next Chapter After 12 Years, NIH Director Francis S. Collins Seeks His Next Chapter