Critical bleeding is associated with a high mortality rate in patients with trauma. JAMA Associate Editor Christopher W. Seymour, MD, MSc, discuses the results of the CRYOSTAT-2 trial with Nicola Curry, MD, Oxford University Hospitals, and Ross Davenport, PhD, Centre for Trauma Sciences, UK. Related Content: Early and Empirical High-Dose Cryoprecipitate for Hemorrhage After Traumatic Injury