This episode discusses three articles about herpes simplex virus (HSV) serologic diagnostic testing options and outlines the 2021 STI Treatment Guidelines recommendations on when to use HSV serology. To view the episode's transcript and references, visit www.std.uw.edu.  Editor and host Dr. Meena Ramchandani is an Assistant Professor of Medicine at the University of Washington (UW) and Medical Director of the Public Health – Seattle & King County Sexual Health Clinic. This podcast is dedicated to an STD [sexually transmitted disease] literature review for health care professionals who are interested in remaining up-to-date on the diagnosis, management, and prevention of STDs.