While human monkeypox is not typically considered an STI, reported cases of this current outbreak in 2022 have been identified at sexual health clinics in different countries and there are features to suggest close human-to-human transmission of this virus is playing a major role. This episode reviews three articles on monkeypox. An article on the effectiveness of oral tecovirimat for treatment is also discussed. For additional information and helpful pictures of lesions, two other 2022 articles are recommended. Clinicians are encouraged to visit the Centers for Disease Control and Prevention to keep updated on the evolving situation.  To view the episode's transcript and references, visit www.std.uw.edu.  Editor and host Dr. Meena Ramchandani is an Assistant Professor of Medicine at the University of Washington (UW) and Medical Director of the Public Health – Seattle & King County Sexual Health Clinic. This podcast is dedicated to an STD [sexually transmitted disease] literature review for health care professionals who are interested in remaining up-to-date on the diagnosis, management, and prevention of STDs.