What do the new Chest Pain Guidelines say about additional noninvasive testing for low risk and intermediate risk patients? Is relief of chest pain with nitroglycerin diagnostic of myocardial ischemia? In this interview, Debabrata Mukherjee, MD, MS and Jeroen J. Bax PhD, MD, FACC, with Jonathan R. Salik, MD, discuss these questions and other top takeaways for the practicing clinician: from the Chest Pain Guidelines.