The short answer to this question, according to a new guideline published in CMAJ, is “No.”In this special episode, CMAJ editor in chief, Dr. Kirsten Patrick, talks to Dr. Eddy Lang, lead author of the guideline entitled Recommendation on instrument-based screening for depression during pregnancy and the postpartum period produced by the Canadian Task Force on Preventive Health Care. They discuss why there’s not enough evidence to support a recommendation to screen routinely, why that doesn’t mean that depression in pregnancy and the postpartum period is not important to diagnose, and in what circumstances use of a screening instrument might be helpful.Blair and Jola will be back next episode.