In this episode, we discuss the teams in the Cells region of the 2022 RheumMadness Tournament. Our DEI discussion topic is increasing diversity in rheumatology clinical trials.Hosts: David Leverenz (Assistant Professor of Medicine at Duke), Guy Katz (Fellow at MGH), Michael Macklin (Resident at UPMC), Michael Cunningham (Fellow at UNC)Learn more about RheumMadness by visiting our website: https://sites.duke.edu/rheummadnessReferences: Anti-NET antibodies: Zuo Y, Yalavarthi S, Gockman K, et al. Anti-Neutrophil Extracellular Trap Antibodies and Impaired Neutrophil Extracellular Trap Degradation in Antiphospholipid Syndrome. Arthritis Rheumatol. 2020;72(12):2130-2135. doi:10.1002/art.41460 Cytokine networks: Simon Q, Grasseau A, Boudigou M, et al. A Proinflammatory Cytokine Network Profile in Th1/Type 1 Effector B Cells Delineates a Common Group of Patients in Four Systemic Autoimmune Diseases. Arthritis Rheumatol. 2021;73(8):1550-1561. doi:10.1002/art.41697 CAR-T cells (1): Mougiakakos D, Krönke G, Völkl S, et al. CD19-Targeted CAR T Cells in Refractory Systemic Lupus Erythematosus. N Engl J Med. 2021;385(6):567-569. doi:10.1056/NEJMc2107725 CAR-T cells (2): Orvain C, Boulch M, Bousso P, Allanore Y, Avouac J. Is There a Place for Chimeric Antigen Receptor-T Cells in the Treatment of Chronic Autoimmune Rheumatic Diseases?. Arthritis Rheumatol. 2021;73(11):1954-1965. doi:10.1002/art.41812 Pim kinases: Maney NJ, Lemos H, Barron-Millar B, et al. Pim Kinases as Therapeutic Targets in Early Rheumatoid Arthritis. Arthritis Rheumatol. 2021;73(10):1820-1830. doi:10.1002/art.41744 SLE clinical trial diversity: Falasinnu T, Chaichian Y, Bass MB, Simard JF. The Representation of Gender and Race/Ethnic Groups in Randomized Clinical Trials of Individuals with Systemic Lupus Erythematosus. Curr Rheumatol Rep. 2018;20(4):20. Published 2018 Mar 17. doi:10.1007/s11926-018-0728-2 RA clinical trial diversity: Strait A, Castillo F, Choden S, et al. Demographic Characteristics of Participants in Rheumatoid Arthritis Randomized Clinical Trials: A Systematic Review. JAMA Netw Open. 2019;2(11):e1914745. Published 2019 Nov 1. doi:10.1001/jamanetworkopen.2019.14745Critical race theory and SLE trial enrollment: Sneed RS, Mason M, Williams JN, et al. Using Critical Race Theory to Understand Trial Participation Among Black Individuals With Systemic Lupus Erythematosus: A Qualitative Study of Patients and Caregivers. Arthritis Care Res (Hoboken). 2021;73(10):1387-1395. doi:10.1002/acr.24635 Intro and Outro music:Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/