Dr. Aki Udupa and Dr. Allen Witt are back to discuss:-Rheuminders from the previous episode on relapsing polychondritis subtypes-Primer on RA pathophysiology-A new study (see below) using longitudinal genomics to provide new insights into the pathogenesis of RA flares and describing a new type of cell: PRIME cells.Reference: Orange DE, Yao V, Sawicka K, Fak J, Frank MO, Parveen S, Blachere NE, Hale C, Zhang F, Raychaudhuri S, Troyanskaya OG, Darnell RB. RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares. N Engl J Med. 2020 Jul 16;383(3):218-228. doi: 10.1056/NEJMoa2004114. PMID: 32668112; PMCID: PMC7546156.Intro and Outro music: Cheery Monday by Kevin MacLeodLink: https://incompetech.filmmusic.io/song/3495-cheery-mondayLicense: http://creativecommons.org/licenses/by/4.0/