Arguably, a clinician’s most important role is providing an accurate and actionable diagnosis for patients. But challenges stand in the way, including tool limitations, inequitable access, and discontinuity of care. In this roundtable Q&A discussion, Urmimala Sarkar, MD, MPH (Zuckerberg San Francisco General Hospital and Trauma Center, UCSF), Jonathan H. Chen, MD, PhD (Stanford Center for Biomedical Informatics Research, Stanford University), and Harvey V. Fineberg, MD, PhD (Gordon and Betty Moore Foundation), discuss issues affecting diagnostic excellence, the emergence of artificial intelligence–driven tools, and ways to make the diagnostic process patient-focused. Hosted by JAMA Editor in Chief Kirsten Bibbins-Domingo, MD, PhD. Related Content: Decoding Artificial Intelligence to Achieve Diagnostic Excellence Diagnostic Excellence Achieving Diagnostic Equity in Cardiovascular Disease Achieving Diagnostic Excellence in the 21st Century Achieving Diagnostic Excellence