Episode 153 hosts Per Winlof, Chief Design Expert of Galderma. Per leads Galderma’s global R&D and is responsible for all of their filler portfolio from the past, the present and into the future. Back in 1990 Per was a microbiology student at university in Uppsala, Sweden. To help supplement his income, he applied for a job at a very small biotech company founded by Dr Bengt Ågerup called ‘Q-Med’. Although fillers were already available (as collagen-based products), Per and his team developed a completely new way of manufacturing fillers made out of a sugar-molecule using bacteria. They launched the world’s first sugar-based dermal filler in 1996. This new product completely revolutionised the world of facial aesthetics. To this day, approximately 95% of dermal fillers are based on this original technology. Q-Med were acquired by Galderma in 2010 and this podcast celebrates the 25th birthday of the world's first modern filler.  We explore: - Per’s background and why he applied for a job at Q-Med? - Who started Q-Med and why? - Who developed the original technology of sugar-based fillers and why they were invented in the first place? - How the idea of facial fillers was conceived? - The key differences between collagen fillers (available in the early 1990’s) and the newer sugar-based fillers - How sugar-based fillers are made in the lab? - The advantages of fillers that don't contain animal products - Why fillers come in a 1ml syringe? - What cross-linking is? - The beginnings of the science of filler rheology: how and why the properties of fillers can differ? - Filler integration vs tissue integration - Whether fillers dissolve or not? - The key safety feature of sugar-based fillers: reversibility and the use of dissolving agents - Whether Per gave us any clues about what’s coming in the future?   Show your support for IA via Patreon Follow IA on Instagram Visit our website  Subscribe to IA on Apple Podcasts Subscribe to IA on Spotify Contact Dr Jake & David  More about Dr Jake Follow Dr Jake on Instagram  Follow David on Instagram  Follow Gillian on Instagram Contact Galderma Australia: www.galderma.com.au