You likely know the expression, Pay It Forward. It’s an important concept for any kind of social awareness, but it can carry special meaning as well in the breast cancer world, particularly in research.That’s because so much of today’s important breakthroughs are built not only on yesterday’s participation of other patients, but, of course, the work of other researchers. It’s a sentiment Dr. Luca Gianni not only knows well, but also puts into practice every day.As you’ll hear, in this important and engaging conversation, Dr. Gianni remains grateful to his mentor – Dr. Gianni Bonadonna – who brought him into the National Institute for the Study and Treatment of Cancer in Milan, Italy some 40 years ago. Based on what he learned there, Dr. Gianni has since delivered numerous breakthroughs in cancer research.Onea main treatment – particularly in women with locally advanced or inflammatory HER2-positive breast cancer.Now he is taking that same mindset – focus on early treatment – to drive his research in an important different direction: To help identify triple negative breast cancer patients most likely to benefit from checkpoint inhibitor therapy before beginning the treatment and those who will do well with chemotherapy alone. Not only would this help find patients with greater likelihood for an improved outcome, of course, but it also could help reduce the extreme costs and toxicity side effects for patients unlikely to benefit.More about Dr. Gianni: He is Director of the Department of Medical Oncology and the head of the Project of Development of New Drugs and Innovative Therapies in Solid Tumors at the San Raffaele Scientific Institute in Milan. He is also Cofounder and President of the Michelangelo Foundation, a non-profit organization designed to advance research in oncology, and chairman of the Michelangelo Breast Cancer Study Group. Dr. Gianni has received several grants and research support, and was awarded the “Gianni Bonadonna Award and Fellowship” by the American Society of Clinical Oncology in 2011 – yes, an award named after his mentor. He also has been a BCRF Investigator since 2018.I connected with Dr. Gianni in his lab in Italy, which left me envious of course that the conversation occurred, as you’ll hear, via computer, rather than in person – say, in a local Milan cafe… Well, we can’t have everything