The Underlying Biology of Drug Resistance with Dr. Sarat Chandarlapaty

Mapping and understanding brain metastasis in breast cancer, with Dr. Priscilla Brastianos: Metastasis, when cancer cells leave the breast and spread to other sites in the body, is the major cause of mortality from breast cancer. The brain is one of the most common organs breast cancer invades, occurring in more than one third of patients with ... by Investigating Breast Cancer

29 min listen

Evaluating natural cancer treatments with Dr. Susan Horwitz: Can life change with a single letter in the mail? For my guest today, it did, and subsequently, so did the lives of millions of people with various forms of cancer, including breast cancer.The letter in question came from the National Cancer Institute in... by Investigating Breast Cancer

32 min listen

What Should I Eat? We asked Dr. Walter Willett: “What should I eat?” It’s a question that Dr. Walter Willett thinks about every day as a researcher focused on the intersection of diet, lifestyle and health. Dr. Willett, a BCRF investigator since 2001, is widely considered a global leader on nutrition ... by Investigating Breast Cancer

35 min listen

Young women and breast cancer, with Dr. Ann Partridge: For young women, a breast cancer diagnosis presents a unique set of challenges not only due to age, but the biology of the disease as well. While a diagnosis under the age of 40 is rare, the disease tends to behave more aggressively. Compared to older br... by Investigating Breast Cancer

42 min listen

Improving breast cancer diagnosis and care in remote and low resource communities, with Dr. Lawrence Shulman: Did you ever think you’d end up working in Africa?Neither did Dr. Lawrence Shulman. But then we never had Paul Farmer as our intern. Dr. Shulman – an oncologist who specializes in breast cancer – did.Farmer, if you don’t know, is the American anthropolog... by Investigating Breast Cancer

29 min listen

The De-Escalation of Therapy, with Dr. Eric Winer: How should we – patients, family, doctors – consider the careful balance in identifying patients who might benefit from less rigorous course of treatment? Dr. Eric Winer, a BCRF investigator since 2003, studies this concept. Known as “de-escalation of t... by Investigating Breast Cancer

32 min listen

BCRF Symposium and Awards Luncheon 2020: Each October, BCRF-funded investigators are honored at the Foundation’s Symposium & Awards Luncheon in New York City. This year, the program was held virtually, without the lunch—but with all of the important conversations and ideas. The annual event ann... by Investigating Breast Cancer

47 min listen

Unraveling Metastatic Breast Cancer, with Dr. Martine Piccart: Dr. Martine Piccart talks to us about the power of collaboration in metastatic breast cancer research Metastasis, the spread of cancer cells from the breast to other sites in the body, is responsible for nearly all breast cancer deaths. Approximately 150... by Investigating Breast Cancer

30 min listen

Focusing on early treatment, with Dr. Luca Gianni: You likely know the expression, Pay It Forward. It’s an important concept for any kind of social awareness, but it can carry special meaning as well in the breast cancer world, particularly in research.That’s because so much of today’s important breakthr... by Investigating Breast Cancer

31 min listen

Developing Personalized Risk Prediction with Dr. Mark Robson: Dr. Mark Robson talks about how he’s working to help identify the right tests for the right person at the right age How can researchers provide more precise risk estimates so that individuals with inherited risks can make informed decisions about their h... by Investigating Breast Cancer

29 min listen

BCRF Symposium & Awards Luncheon: Live from New York City: Every October, BCRF-funded researchers are honored at the annual Symposium & Awards Luncheon in New York City. This is when BCRF makes its formal announcement of research grants for the upcoming year and recognizes its investigators for their devotion to... by Investigating Breast Cancer

72 min listen

Reflecting on Thirty Years of Progress with Dr. Larry Norton: Since Evelyn H. Lauder and Dr. Larry Norton launched BCRF in 1993 remarkable advances in breast cancer prevention, diagnosis, treatment, survivorship, and metastasis have been made. But there is still critical work to be done. The Foundation is movin... by Investigating Breast Cancer

38 min listen

Improving the Quality of Life for Breast Cancer Patients and Survivors with Professor Dame Lesley Fallowfield: How do you measure quality of life? As researchers across fields discover new drug therapies or disease prevention—in breast cancer as well as other fields—science finds innumerable ways to measure physical results. But what about the social, behavioral,... by Investigating Breast Cancer

34 min listen

The Promise and Potential of Breast Cancer Vaccines with Dr. Karen Anderson: One key goal in developing precision vaccines and immune therapies is to reduce the risk of breast cancer recurrence. Yet currently, there is only one FDA-approved immunotherapy drug for breast cancer, and it benefits just a small subset of women. In thi... by Investigating Breast Cancer

29 min listen

Breast Cancer Care and COVID-19: From the Frontlines with Dr. Judy Garber: Breast cancer—and any cancer—can be incredibly stressful under the best of circumstances for patients, survivors, and their families. In this time of the novel coronavirus (COVID-19), concerns can feel like they’re rising exponentially. So, what do we al... by Investigating Breast Cancer

22 min listen

The Underlying Biology of Drug Resistance with Dr. Sarat Chandarlapaty: Advances in cancer therapy have dramatically contributed to the decline in breast cancer deaths over the last three decades. But even with these advances, drug resistance—when tumors stop responding to anti-cancer drugs—remains a serious clinical challen... by Investigating Breast Cancer

34 min listen

New Approaches to Reducing Repeat Breast Cancer Surgeries with Dr. Mehra Golshan: There are many challenges in managing breast cancer. Top among them is the fact that initial breast conserving surgeries often miss vestiges of a patient’s tumor. In fact, up to 40 percent of women require another procedure following lumpectomy. Not only... by Investigating Breast Cancer

33 min listen

Perfecting and Personalizing Risk Assessment with Dr. Katherine Nathanson: While breast cancer is not typically caused by inherited factors, as many as 10-15 percent of people diagnosed with breast cancer carry a known genetic mutation. The most well-known mutations are in the BRCA1 and BRCA2 genes. But these only account for 5... by Investigating Breast Cancer

22 min listen

A Cross-disciplinary Approach to Breast Cancer Research with Dr. Antonio Wolff: In the fight to understand and solve breast cancer, “it takes a village.” In this case, the village is more like a globally connected series of research labs, scientists, patients, funders and more. In other words, something that looks a lot like the Tr... by Investigating Breast Cancer

42 min listen

BCRF’s 2021 Boston Hot Pink Symposium: BCRF’s annual Boston Hot Pink Luncheon and Symposium convenes the Foundation’s dedicated New England–based supporters to honor the area’s investigators and raise additional funds for lifesaving breast cancer research. This year’s virtual program included... by Investigating Breast Cancer

28 min listen

Connecting the Dots Between Breast Cancer Risk and Obesity, with Dr. Vared Sterns: Women with breast cancer who are overweight or obese experience inferior outcomes compared to those with normal weight despite receiving optimal therapies. Dr. Vered Stearns discusses researching ways to reduce breast cancer recurrence through effective ... by Investigating Breast Cancer

32 min listen

Improving National and Global Racial Disparities in Breast Cancer Care with Dr. Funmi Olopade: Women of African descent are more likely to be diagnosed with aggressive breast cancers than white women and are more likely to die from their disease regardless of its type or stage. For those living in remote or low-resource areas, limited access to sc... by Investigating Breast Cancer

53 min listen

Exploring the Many Intersections of Health Equity in Latin America with Dr. Jeffrey Weitzel: While genetic testing and counseling for breast cancer has been available in the U.S. for many years, accessing these services in Mexico and the rest of Latin America is more challenging due to limited resources. Leading genetics researcher and oncologis... by Investigating Breast Cancer

40 min listen

A Closer Look at the Evolution of Breast Cancer Cells with Dr. Kornelia Polyak: The immune system plays a critical role in tumor growth by attacking cancer cells with white blood cells. Cancer cells that survive this immune attack can become invasive and metastatic (a process called immune escape). In this episode of Investigating B... by Investigating Breast Cancer

38 min listen

Understanding Radiation Resistance and Barriers to Quality Care with Dr. Lori Pierce: For so many breast cancer patients, radiation therapy can bring extraordinary benefits—top among them improved survival rates and reduced recurrence. But there are also challenges and questions: Why do some people experience a recurrence after treatment?... by Investigating Breast Cancer

34 min listen

Understanding and Targeting Triple-Negative Breast Cancer with Dr. Jill Bargonetti: The complexities of triple-negative breast cancer (TNBC) can sometimes make it hard to understand. It’s an aggressive form of breast cancer that is more likely to spread to other tissues––a process called metastasis. BCRF Investigator since 2005, Dr... by Investigating Breast Cancer

29 min listen

Finding and Targeting “Sleeping” Cancer Cells with Dr. Angela DeMichele: What are dormant cancer cells and how they lead to a clearer understanding of the cancer in remission? Why do particular cancerous cells behave differently than others? BCRF Investigator since 2017, Dr. Angela DeMichele, discusses her work to uncover... by Investigating Breast Cancer

28 min listen

Artificial Intelligence and the Future of Breast Cancer Research with Dr. Connie Lehman: Effective medicine has always relied on clear and verifiable diagnoses. Of course, for patients, the wait and uncertainty of diagnostics can be especially trying. BCRF investigator since 2019, Dr. Connie Lehman, is among the scientists and practitioners ... by Investigating Breast Cancer

31 min listen

The Progress and Future of Breast Cancer Vaccines with Dr. Nora Disis: In this latest episode of Investigating Breast Cancer, Dr. Nora Disis talks about prevention, treatment, breast cancer vaccine research, and more. Her research focuses on identifying ways to boost the immune response in breast cancer patients to impr... by Investigating Breast Cancer

28 min listen

Investigating What Drives Recurrence and Metastasis with Dr. Christina Curtis by Investigating Breast Cancer

29 min listen

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The Underlying Biology of Drug Resistance with Dr. Sarat Chandarlapaty

The Underlying Biology of Drug Resistance with Dr. Sarat Chandarlapaty

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