Ben Lehner is a Professor and Coordinator of the Systems Biology Programme at the Centre for Genomic Regulation in Barcelona. In this episode, Ben talks with us about how careerism is bad for science. He describes how he avoids being limited to the confines of individual fields and disciplines and his strategy for dealing with the unpredictability of science. He also discusses with us how to not get attached to any particular idea in order to really make progress. In his work, Ben explores how one can predict the biological differences among individuals from their genomes. His tools are experiments and computational analyses, mostly working on yeast and worms. Ben has been awarded many prestigious awards, including the Gold Medal from the European Molecular Biology Organization.