George Church, professor of genetics at Harvard Medical School, leads a large research group at the Wyss Institute for Biologically Inspired Engineering. A pioneer in the fields of personalized genomics and synthetic biology, he has co-founded over 50 biotech companies. In 2017, Time magazine named him one of the 100 most influential people in the world. In this conversation, we discuss the importance of embracing outliers and taking calculated risks – it's not about never failing, it's about failing a million times a day. As Yogi Berra said, "When you come to a fork in the road, take it!”  George argues that you can change the world as long as you don't care who gets the credit. He recommends shooting for the stars – maybe you'll hit the moon. This episode was supported by Research Theory (researchtheory.org). For more information on Night Science, visit https://www.biomedcentral.com/collections/night-science .