As the largest public insurance program in the US, Medicare has an outsize influence in how many people in the US access and receive health care. Recently appointed Director of Center for Medicare Meena Seshamani, MD, PhD, joins JAMA Associate Editor Karen Joynt Maddox, MD, for a discussion of equitable, patient-centered approaches to health care delivery, and how her own experiences as a physician have illuminated how she leads the program. Related Content: Center for Medicare Director Envisions Holistic Approach to Health Care Leading Medicare: Q&A With Medicare Director Meena Seshamani Health System Factors Related to Overuse of Health Services in Medicare Leveraging Medicare to Advance Health Equity